Pharmaceutical wholesalers
EDI with McKesson, Cardinal Health, and Cencora
US Rx distribution is dominated by McKesson, Cardinal Health, and Cencora (formerly AmerisourceBergen). Each runs its own EDI onboarding, test gates, and DSCSA expectations. Certification calendars are partner-owned.
McKessonCardinal HealthCencorawholesaler EDI
What to know
US Rx distribution is dominated by McKesson, Cardinal Health, and Cencora (formerly AmerisourceBergen). Each runs its own EDI onboarding, test gates, and DSCSA expectations. Certification calendars are partner-owned.
- McKesson pharmaceutical distribution EDI typically covers order-to-cash (850/855/856/810), product activity (852 where contracted), and DSCSA/traceability companion data. Onboarding often spans multiple test cycles; confirm current guide in McKesson supplier portals.
- Cardinal Health supplier programs emphasize distribution X12, program-specific chargeback/rebate sets, and DSCSA-related exchanges for in-scope products. Expect structured test plans and facility/account alignment.
- Cencora is the current brand for AmerisourceBergen pharmaceutical distribution. EDI onboarding covers order-to-cash, chargeback/rebate families where contracted, product activity, and DSCSA companion requirements. Prefer 'Cencora' in new copy; keep AmerisourceBergen redirects for search.
- Each wholesaler owns test gates and production cutover — SignalEDI prepares mappings, validation, and evidence packs.
- ICP includes manufacturers selling into the Big 3 and specialty pharmacies / smaller distributors trading upstream or laterally.
Readiness language only — confirm every McKesson, Cardinal Health, and Cencora requirement in the partner implementation guide. SignalEDI does not issue DSCSA or FDA certifications.